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Published on: March 3, 2023
Safety of Endoscopy in Heritable Connective Tissue Disorders
Saikiran M Kilaru1, Kenneth J Mukamal2, Judy W Nee2
1New York University School of Medicine, New York, New York, USA.
Introduction:
Little is known about the gastrointestinal manifestations or safety of endoscopy among patients with heritable connective tissue disorders such as Marfan syndrome or Ehlers-Danlos syndrome (EDS).
Methods:
We conducted an electronic cross-sectional survey nested within preexisting registries of patients with heritable connective tissue disorders and examined self-reported rates of endoscopic complications.
Results:
The rate of endoscopy-related perforation was 9.4% (95% confidence interval 2.0%-25.0%) among individuals with vascular EDS, <1% in classical and hypermobility-type EDS, and zero in Marfan syndrome (P < 0.001). Spontaneous intestinal perforation was also significantly higher in the vascular EDS group.
Discussion:
Clinicians should consider noninvasive screening methods for patients with vascular EDS.
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