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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Nicotinamide Deficiency in Primary Open-Angle Glaucoma.

Judith Kouassi Nzoughet1, Juan Manuel Chao de la Barca1,2, Khadidja Guehlouz3

  • 1Equipe Mitolab, Unité Mixte de Recherche MITOVASC, CNRS 6015, INSERM U1083, Université d'Angers, Angers, France.

Investigative Ophthalmology & Visual Science
|June 12, 2019
PubMed
Summary
This summary is machine-generated.

Plasma nicotinamide levels are significantly lower in individuals with primary open-angle glaucoma (POAG). This finding suggests nicotinamide supplementation could be a future therapeutic strategy for glaucoma treatment.

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Area of Science:

  • Ophthalmology
  • Nutritional Science
  • Biochemistry

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide.
  • Nicotinamide, a form of vitamin B3, plays a crucial role in cellular energy metabolism and DNA repair.

Purpose of the Study:

  • To investigate and compare plasma nicotinamide concentrations in patients with POAG versus healthy controls.
  • To explore the potential link between reduced nicotinamide levels and the pathogenesis of POAG.

Main Methods:

  • Employed liquid chromatography coupled to high-resolution mass spectrometry for semiquantitative analysis of plasma nicotinamide.
  • Utilized a targeted quantitative liquid chromatography-mass spectrometry method for precise nicotinamide concentration measurements.
  • Included an initial cohort of POAG patients and controls, and a subsequent replicative cohort for validation.

Main Results:

  • Significantly lower plasma nicotinamide concentrations were observed in POAG individuals compared to age- and sex-matched controls in both semiquantitative and quantitative analyses.
  • The POAG group exhibited approximately 30-33% lower mean nicotinamide levels compared to the control group (P < 0.05).
  • Consistent findings were observed across both the initial and replicative cohorts, confirming the reduced nicotinamide levels in POAG.

Conclusions:

  • The study concludes an association between glaucoma and diminished plasma nicotinamide levels.
  • Results suggest that nicotinamide supplementation may represent a potential future therapeutic avenue for managing POAG.
  • Further large-scale studies are warranted to validate these preliminary findings and explore therapeutic efficacy.