Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

712
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
712
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

618
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
618
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

831
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
831
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

214
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
214
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

271
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
271
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

199
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
199

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Health Mindset in Pediatric Inflammatory Bowel Disease: Exploring the Relationship Between Health Mindset and Key Physical and Psychosocial Outcomes.

Children (Basel, Switzerland)·2026
Same author

Integrative medicine consults in a pediatric hospital: A case series.

Explore (New York, N.Y.)·2025
Same author

Self-Compassion in Adolescents and Young Adults With Inflammatory Bowel Disease: Relationship of Self-Compassion to Psychosocial and Physical Outcomes.

Inflammatory bowel diseases·2024
Same author

A Specific Carbohydrate Diet Virtual Teaching Kitchen Curriculum Promotes Knowledge and Confidence in Caregivers of Pediatric Patients with Inflammatory Bowel Disease.

Nutrients·2023
Same author

Perspectives on Specific Carbohydrate Diet Education from Inflammatory Bowel Disease Patients and Caregivers: A Needs Assessment.

JPGN reports·2023
Same author

The Risk of Colonic Strictures with Colitis Following Hemolytic Uremic Syndrome: A Case Report of a Toddler.

JPGN reports·2023

Related Experiment Video

Updated: Jan 23, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

2.0K

Integrative Approach to Pediatric Nausea.

Jenna Arruda, Ann Ming Yeh

    Pediatric Annals
    |June 12, 2019
    PubMed
    Summary

    Pediatric nausea can be effectively managed with various non-pharmacologic therapies. Emerging evidence supports mind-body interventions, botanicals like ginger, and acupuncture for treating nausea in children.

    Area of Science:

    • Pediatric Gastroenterology
    • Complementary and Alternative Medicine

    Background:

    • Nausea is a common and distressing symptom in children.
    • Its complex pathophysiology involves neurological, gastrointestinal, and psychological factors.

    Purpose of the Study:

    • To review pharmacologic and non-pharmacologic therapies for pediatric nausea.
    • To highlight emerging evidence for complementary and alternative medicine (CAM) approaches.

    Main Methods:

    • Literature review of studies on pediatric nausea treatments.
    • Analysis of evidence for mind-body interventions, botanicals, aromatherapy, and acupuncture.

    Main Results:

    • Pharmacologic options exist, but non-pharmacologic therapies show promise.

    More Related Videos

    An Integrated Approach for Microprotein Identification and Sequence Analysis
    09:37

    An Integrated Approach for Microprotein Identification and Sequence Analysis

    Published on: July 12, 2022

    4.0K
    Guidelines for Elective Pediatric Fiberoptic Intubation
    11:19

    Guidelines for Elective Pediatric Fiberoptic Intubation

    Published on: January 17, 2011

    18.4K

    Related Experiment Videos

    Last Updated: Jan 23, 2026

    Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
    05:56

    Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

    Published on: June 21, 2024

    2.0K
    An Integrated Approach for Microprotein Identification and Sequence Analysis
    09:37

    An Integrated Approach for Microprotein Identification and Sequence Analysis

    Published on: July 12, 2022

    4.0K
    Guidelines for Elective Pediatric Fiberoptic Intubation
    11:19

    Guidelines for Elective Pediatric Fiberoptic Intubation

    Published on: January 17, 2011

    18.4K
  • Hypnosis, biofeedback, ginger, peppermint oil, aromatherapy, and acupuncture have emerging evidence.
  • These CAM therapies offer potential alternatives or adjuncts to conventional treatment.
  • Conclusions:

    • Non-pharmacologic therapies, including CAM, are valuable options for managing pediatric nausea.
    • Further research is warranted to solidify the efficacy of these emerging treatments.
    • A multimodal approach may be beneficial for addressing nausea in children.