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Updated: Jan 23, 2026

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
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Precision Oncology: Three Small Steps Forward

Hannah C Wise1, David B Solit2

  • 1Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Cancer Cell
|June 12, 2019
PubMed

Insights

Personalized cancer treatments are limited. Detecting drug targets in cell-free DNA, comprehensive molecular profiling, and combination therapies can expand personalized oncology benefits.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Personalized oncology aims to tailor cancer treatments to individual patients.
  • Current personalized approaches benefit only a limited patient population.
  • Advances in molecular diagnostics are crucial for expanding treatment options.

Purpose of the Study:

  • To explore strategies for broadening the reach of personalized cancer therapies.
  • To highlight the potential of novel molecular profiling techniques.
  • To discuss the role of combination regimens in precision oncology.

Main Methods:

  • Review of current literature on personalized oncology.
  • Analysis of emerging technologies for molecular profiling, including cell-free DNA analysis.
  • Evaluation of strategies for developing personalized combination therapies.

Main Results:

  • Cell-free DNA analysis enables the detection of actionable drug targets.
  • Integrating transcriptional analyses provides a more comprehensive molecular profile.
  • Personalized combination regimens show promise for improved patient outcomes.

Conclusions:

  • Expanding personalized oncology requires advancements in target detection and profiling.
  • Comprehensive molecular profiling, including transcriptomics, is key.
  • Personalized combination therapies represent a promising avenue for broader patient benefit.

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