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Updated: Jan 23, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
Silver and gold doped hydroxyapatite nanocomposites for enhanced bone regeneration
Vijay Bhooshan Kumar1, Deepak Kumar Khajuria2, David Karasik2,3
1Bar-Ilan Institute for Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Ramat Gan-5290002, Israel.
None:
We report the osteogenic potential of silver (Ag), gold (Au), or silver-gold doped hydroxyapatite nanoparticles (Ag-Au-HA) in zebrafish (ZF) jawbone regeneration (JBR) model. The hydroxyapatite (HA, Ca10(PO4)6(OH)2), Ag-HA, Au-HA, and Ag-Au-HA nanomaterials were synthesized by the co-precipitation procedure. The surface structures of Ag-HA, Au-HA, HA, and Ag-Au-HA were analysed by scanning electron microscopy, transmission-electron microscopy (TEM), x-ray diffraction, Fourier transform infrared (FTIR), UV-vis, energy dispersive x-ray spectroscopy (EDS), elemental mapping, and laser fluorescent spectroscopy. The TEM and EDS analysis confirmed that the Ag and Au are associated with the surface of HA nanoparticle. The chemical structure of HA, Ag-HA, Au-HA, and Ag-Au-HA nanoparticles was validated by FTIR and EDS analysis. We observed that Ag and Au are associated with HA nanoparticles by electrostatic, wander wall, and electrostatic and H-bonding interaction. The effect of Ag-HA, Au-HA, and Ag-Au-HA nanoparticles on bone regeneration was confirmed by ZF JBR model. The significant growth of ZF bone regeneration was observed in Ag-Au-HA nanoparticles as compared with HA, Ag-HA, and Au-HA nanoparticles. These results indicating a therapeutic potential of Ag-Au-HA compositions suggest these nanomaterials would be excellent for bone regeneration and fracture healing.
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