[Dynamics of endogenous bacterial nitrite formation in the stomach. 3. Dependence of nitrate and nitrite...

The nitrate and nitrite concentration of 96 fasting gastric juice samples of young healthy volunteers were analysed. Two different methods have been used to take the gastric juice: 54 secrete samples were taken directly from the stomach, 42 secrete samples were taken after instillation of 500 ml sterile nitrite and nitrate free NaCl solution ("gastric-washing"). It could be shown that the expected high dilution of nitrite and nitrate concentration after gastric washing does not occur. A possible explanation might be that the solubilisation we could formerly observe in a biological pattern leads to a release of ions. This fact is very important for the question of endogen synthesis of cancerogenic N-nitroso compounds, because high nitrite and nitrate concentrations are subjects of interests as precursors of these compounds.