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Related Concept Videos

SI Units: 2019 Redefinition01:13

SI Units: 2019 Redefinition

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Measurement is an indispensable part of analytical chemistry. The result of measurement helps quantify a substance's physical property and compare it with the physical property of another substance. Each measurement comprises two components - a number indicating the magnitude and a unit of measurement as a standard for comparison. Further, the same quantity can be measured using different units of measurement, which leads to differences in magnitude.
A standard set of units has been defined...
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Schemas01:42

Schemas

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A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
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Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
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Cutaneous lymphomas-An update 2019.

Werner Kempf1,2, Anne-Katrin Zimmermann1, Christina Mitteldorf3

  • 1Kempf und Pfaltz Histologische Diagnostik, Zurich, Switzerland.

Hematological Oncology
|June 13, 2019
PubMed
Summary
This summary is machine-generated.

Primary cutaneous lymphomas (CL) are extranodal lymphomas, with cutaneous T-cell lymphomas being most common. Updated classifications and new biomarkers improve diagnosis and targeted therapies for CL.

Keywords:
B cellT-cellclassificationcutaneousdermatopathologydiagnosislymphomaskin

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Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Primary cutaneous lymphomas (CL) are the second most frequent extranodal lymphomas.
  • Cutaneous T-cell lymphomas (CTCL) constitute the majority of CL cases.
  • Classification follows the WHO 2017 and WHO-EORTC 2018 guidelines.

Purpose of the Study:

  • To review recent advancements in the classification, diagnosis, and treatment of primary cutaneous lymphomas.
  • To highlight new provisional entities and expanded understanding of existing CL subtypes.
  • To emphasize the importance of clinico-pathological correlation and emerging biomarkers.

Main Methods:

  • Review of updated WHO and WHO-EORTC classifications for skin tumors.
  • Analysis of recent studies on histological and genetic spectrum of CL.
  • Evaluation of new biomarkers and genetic alterations in CL pathogenesis.
  • Assessment of advancements in targeted therapies for aggressive lymphomas.

Main Results:

  • Introduction of provisional entities like primary cutaneous acral CD8+ T-cell lymphoma and EBV-positive mucocutaneous ulcer.
  • Expanded histological and genetic understanding of lymphomatoid papulosis.
  • Delineation of prognostic subtypes for entities such as folliculotropic mycosis fungoides and marginal zone lymphoma.
  • Identification of novel biomarkers and genetic alterations driving CL pathogenesis.

Conclusions:

  • Accurate diagnosis of CL requires robust clinico-pathological correlation due to overlapping features.
  • Recent updates in classification and understanding of CL entities enhance diagnostic precision.
  • Emerging biomarkers and targeted therapies offer improved treatment strategies, especially for aggressive CL forms.