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Biological, Medical, and Other Tissue Variables Affecting Biospecimen Utilization
Dennis Otali1, Sameer Al Diffalha1, William E Grizzle1,2
11 Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama.
Biopreservation and Biobanking
|June 13, 2019
Summary
Bioresources provide critical biospecimens for research but face challenges in tissue utilization. Addressing variability factors and improving investigator education can maximize the use of these valuable research resources.
Area of Science:
- Biomedical research
- Biobanking
- Pathology
Background:
- Bioresources are essential for biomedical research, supplying high-quality biospecimens.
- Biorepositories face challenges with increasing inventories and low tissue utilization rates.
- Biospecimen characteristics can introduce variability and limit research utility.
Purpose of the Study:
- To review technical characteristics of biospecimens impacting research utility.
- To identify challenges affecting biospecimen utilization in biorepositories.
- To propose strategies for maximizing biospecimen use.
Main Methods:
- Literature review of biospecimen technical characteristics and utilization challenges.
- Analysis of factors contributing to morphological and molecular variability.
- Discussion of current biorepository operational and investigator-related issues.
Main Results:
- Biospecimen variability stems from donor factors, preanalytical issues, and technical handling.
- Challenges include investigator awareness, tissue availability, ischemia times, and storage-related molecular changes.
- Inadequate understanding of biospecimen properties limits their effective use.
Conclusions:
- Maximal biospecimen utilization requires continuous education for investigators on variability factors.
- Careful review of investigator requests, including pathological assessment, is crucial.
- Direct communication between bioresource personnel and investigators can resolve application queries.
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