Effects of a rehabilitation program on microvascular function of CHD patients assessed by near-infrared spectroscopy

This study aimed to evaluate whether near-infrared spectroscopy (NIRS)-derived reperfusion slope would detect the effects of a 12-week rehabilitation program on lower limb microvascular responsiveness in patients with coronary heart disease (CHD). Ten CHD patients (7 males and 3 females; 57.3 ± 7.6 years) underwent 12 weeks of drug treatment and high-intensity interval training (HIIT), 2 times per week (40 min/session). Microvascular responsiveness was assessed by using NIRS assessment of muscle oxygen saturation (StO₂ ) combined with a vascular occlusion test (VOT) (NIRS-VOT). NIRS-VOT measures were taken at pre- and postintervention, and microvascular responsiveness was evaluated by examining the slope 2 of re-oxygenation rate (slope 2 StO₂ ) and the area under the curve (StO_2AUC ) of StO₂ signal following cuff release subsequent to a 5-min occlusion period. The slope 2 StO₂ was significantly steeper after 12 weeks of training (4.8 ± 1.6% sec^-1 ) compared to the pretraining (3.1 ± 1.6% sec^-1 ) (P < 0.05). The area under the curve for the change in the % StO₂ signal during re-oxygenation increased significantly from 3494 ± 2372%∙sec at pretraining to 9006 ± 4311%∙sec at post-training (P < 0.05). NIRS-VOT technique detected the improvements of 12 weeks of rehabilitation program in the lower limb microvascular responsiveness of CHD patients.