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N-Phenoxyamides as Multitasking Reagents: Base-Controlled Selective Construction of Benzofurans or
Ming Li1, Jia-Hui Wang1, Wei Li1
1State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering , Qingdao University of Science & Technology , Qingdao 266042 , China.
Abstract:
An efficient method to selectively construct benzofuran and dihydrobenzofuro[2,3- d]oxazole derivatives has been successfully established by means of base-controlled cyclization of N-phenoxyamides with 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1 H)-one (TIPS-EBX). N-phenoxyamides as multitasking reagents have triggered two different cascade reaction sequences. This is the first example of using TIPS-EBX for the transformation of C(sp) to either C(sp2) or C(sp3) under metal-free conditions.
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