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Related Experiment Video

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Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
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Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral Sclerosis.

Timothée Lenglet1,2, Jonathan Mirault3, Marie Veyrat-Masson3

  • 1Département de Neurologie, Centre de Référence SLA-IdF, Hôpital Pitié Salpêtrière, AP-HP, Paris, France.

Frontiers in Neuroscience
|June 14, 2019
PubMed
Summary

Amyotrophic lateral sclerosis (ALS) patients can use the novel Eye-On-Line device to control eye-movements for communication. Most ALS participants successfully eye-wrote recognizable digits, offering a new communication method for those with motor impairments.

Keywords:
amyotrophic lateral sclerosisassisted communication devicesmotor learningpilot clinical studysmooth-pursuit eye movements

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Rehabilitation Medicine

Background:

  • Amyotrophic lateral sclerosis (ALS) progressively impairs voluntary muscles, severely affecting communication.
  • Existing communication aids often fail as ALS advances, necessitating innovative solutions.

Purpose of the Study:

  • To assess the efficacy of the Eye-On-Line (EOL) device for communication in ALS patients.
  • To evaluate if ALS subjects can voluntarily control smooth-pursuit eye-movements (SPEM) for eye-writing.

Main Methods:

  • Twelve ALS participants with preserved eye-movements were trained to use the EOL device over six visits.
  • Recognition rates of eye-written digits (0-9) by naive readers were compared between ALS and control groups.
  • Oculomotor performance and device safety were monitored.

Main Results:

  • Nearly 69.4% of eye-written digits from ALS subjects were recognized, comparable to 67.3% in controls.
  • Significant inter-individual variability in performance was observed in both groups.
  • Transient fatigue and eye itching were reported adverse events; one ALS subject withdrew.

Conclusions:

  • Most ALS participants demonstrated the ability to produce recognizable eye-written digits using the EOL device.
  • The EOL system offers a novel, voluntary communication method for individuals with severe motor disabilities.
  • Further refinement may be needed to improve legibility and user comfort.