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Related Experiment Videos

Plasminogen activators in developing peripheral nervous system, cellular origin and mitogenic effect.

A Baron-Van Evercooren1, P Leprince, B Rogister

  • 1Unité INSERM 134, Hôpital de la Salpétrière, Paris, France.

Brain Research
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

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Neurons control Schwann cell proliferation via urokinase plasminogen activator (uPA). This study reveals a novel neuronal signaling pathway in the developing nervous system, independent of plasminogen, highlighting uPA

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Dorsal root ganglia (DRG) in newborn rats release two types of plasminogen activators (PAs): urokinase (UK) and tissue (tPA).
  • UK is secreted by neurons, while tPA is released by Schwann cells.
  • Schwann cell proliferation is influenced by external factors, including mitogens like choleratoxin.

Purpose of the Study:

  • To investigate the roles of UK and tPA in regulating Schwann cell proliferation in the developing nervous system.
  • To determine if plasminogen is necessary for PA-mediated effects on Schwann cells.
  • To elucidate a potential mechanism for neuronal control over Schwann cell development.

Main Methods:

  • Culturing newborn rat dorsal root ganglia and associated cells.

Related Experiment Videos

  • Measuring the release of UK and tPA from neuronal and Schwann cell populations.
  • Assessing the effect of purified UK and tPA on Schwann cell proliferation in vitro, with and without plasminogen.
  • Utilizing choleratoxin to modulate tPA release from Schwann cells.

    • Main Results:

    • Neurons secrete UK, while Schwann cells secrete tPA.
    • UK, but not tPA, significantly stimulates Schwann cell proliferation in a dose-dependent manner.
    • This mitogenic effect of UK on Schwann cells occurs even in the absence of plasminogen.
    • Cholera toxin modulates tPA release from Schwann cells, but does not directly impact Schwann cell proliferation stimulated by UK.

    Conclusions:

    • Neuronal-derived UK is a key regulator of Schwann cell proliferation during development.
    • The mechanism involves a substrate other than plasminogen, suggesting novel PA functions in the nervous system.
    • This identifies a new pathway for neuronal regulation of glial cell development and function.