Managing depression in the patient with cancer

Depression is the most common psychiatric problem encountered among patients with cancer. The acute stress response, which occurs at pivotal points during the course of illness, is normal. However, severe or protracted depressive symptoms should be evaluated and treated. The treatment of depression, which often involves a combined regimen of psychotherapy and psychopharmacologic intervention, can result in improved compliance with therapy, a greater tolerance for the disease and its outcome, and an improved quality of life.