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Human rotavirus in Iran; molecular epidemiology, genetic diversity and recent updates on vaccine advances

Shadi Tavakoli Nick1,2, Seyed Reza Mohebbi3, Amir Ghaemi4

  • 1Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Gastroenterology and Hepatology From Bed to Bench
|June 14, 2019
PubMed

Insights

Human rotavirus causes severe gastroenteritis in young children worldwide. This review examines rotavirus strains in Iran, vaccine impact, and ongoing research to control this significant public health threat.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Human rotavirus is a leading cause of severe gastroenteritis in children under five globally.
  • Rotavirus infections resulted in significant hospitalizations and deaths, particularly in low-income nations, before vaccine implementation.
  • Rotaviruses are classified by G and P genotypes, with specific strains being most prevalent worldwide.

Purpose of the Study:

  • To review the frequency and molecular epidemiology of rotavirus in Iran.
  • To discuss the current genetic diversity of rotavirus strains circulating in Iran.
  • To provide an overview of rotavirus vaccine research advancements.

Main Methods:

  • Review of molecular epidemiological surveys on rotavirus strains.
  • Analysis of rotavirus genotype prevalence data.
  • Synthesis of information on rotavirus vaccine development and implementation.

Main Results:

  • G1P[8] is identified as the predominant rotavirus genotype in Iran, though other genotypes are also present.
  • Rotavirus vaccines (Rotarix and RotaTeq) are globally available to control infection.
  • The study highlights the ongoing genetic diversity of rotaviruses in Iran.

Conclusions:

  • Understanding rotavirus epidemiology in Iran is crucial for public health strategies.
  • Rotavirus vaccines have been recommended by the WHO for childhood immunization programs.
  • Continued research into rotavirus and vaccine development is essential for disease control.

Keywords:
DiarrheaGastroenteritisImmunization programMolecular epidemiologyRotavirusVaccine

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