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Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid Leukemia

Nicolas Chapuis1,2,3,4,5, Laury Poulain1,2,3,4, Rudy Birsen1,2,3,4

  • 1INSERM U1016, Institut Cochin, Paris, France.

Frontiers in Oncology
|June 14, 2019
PubMed

Insights

Metabolic reprogramming fuels cancer cell growth. Targeting these metabolic changes shows promise for treating acute myeloid leukemia (AML), offering new therapeutic avenues.

Area of Science:

  • Oncology
  • Metabolic pathways
  • Cancer cell biology

Background:

  • Metabolic reprogramming is a hallmark of cancer, supporting uncontrolled cell growth and proliferation.
  • Acute myeloid leukemia (AML) cells exhibit significant metabolic alterations.
  • Targeting cancer metabolism presents a promising therapeutic strategy.

Purpose of the Study:

  • To review recent findings on metabolic deregulation in AML.
  • To summarize the implications of these metabolic changes in leukemogenesis.
  • To highlight the therapeutic potential of targeting metabolic pathways in AML.

Main Methods:

  • Literature review of recent studies on AML metabolism.
  • Analysis of metabolic adaptations in various AML subtypes.
  • Synthesis of data on therapeutic strategies targeting metabolic pathways.

Main Results:

  • Recent reports expand the scope of metabolic targeting in AML beyond IDH1/2 mutations.
  • Specific metabolic pathways are crucial for AML cell survival and proliferation.
  • Targeting metabolic vulnerabilities can inhibit AML progression.

Conclusions:

  • Metabolic reprogramming is a critical driver of leukemogenesis in AML.
  • Targeting metabolic pathways offers a viable and expanding therapeutic approach for AML.
  • Further research into AML metabolic dependencies will uncover novel treatment strategies.
Keywords:
acute myeloid leukemiaamino-acidfatty acid oxidationglycolysishematopoiesismetabolismoxidative phosphorylationtargeted therapy

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