Related Experiment Video
Updated: Jan 23, 2026
10:39
Automated Analysis of Intracellular Phenotypes of Salmonella Using ImageJ
Published on: August 9, 2022
3.4K
The superexacerbator phenotype in patients with COPD: a descriptive analysis.
Lowie E G W Vanfleteren1,2, Lotte M C Boonen1, Martijn A Spruit1,3,4
1CIRO, Horn, The Netherlands.
ERJ Open Research
|June 14, 2019
Summary
Superexacerbators are common in patients with chronic obstructive pulmonary disease (COPD) starting rehabilitation. These individuals experience more severe disease and poorer outcomes overall.
Area of Science:
- Pulmonary Medicine
- Respiratory Health
Background:
- Chronic obstructive pulmonary disease (COPD) is a progressive respiratory illness.
- Frequent exacerbations significantly impact patient prognosis and healthcare burden.
Purpose of the Study:
- To determine the prevalence of superexacerbators in COPD patients entering pulmonary rehabilitation.
- To assess the association between superexacerbation status and overall disease severity.
Main Methods:
- Retrospective analysis of patient data from a pulmonary rehabilitation program.
- Identification of superexacerbators based on exacerbation frequency.
- Assessment of disease severity using standard clinical parameters.
Main Results:
- Superexacerbators were found to be highly prevalent among patients entering rehabilitation.
- Patients identified as superexacerbators exhibited worse overall disease status compared to non-superexacerbators.
Conclusions:
- The high prevalence of superexacerbators in this population highlights a critical subgroup needing targeted interventions.
- Identifying superexacerbators early in rehabilitation may allow for more intensive management strategies to improve outcomes.
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K
01:26COPD: Management Using Bronchodilators and Corticosteroids
755
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
755
01:30Pleural Disorders: Types and Brief Description
639
The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
639
01:22Eulerian and Lagrangian Flow Descriptions
1.9K
Fluid flow analysis is critical in many scientific and engineering disciplines, and two principal approaches are used to describe this flow: the Eulerian and Lagrangian methods. These methods offer different perspectives on monitoring and analyzing the motion of fluids, each with distinct advantages depending on the scenario.
The Eulerian method focuses on fixed points in space where fluid properties, such as velocity, pressure, and temperature, are observed as the fluid moves between these...
The Eulerian method focuses on fixed points in space where fluid properties, such as velocity, pressure, and temperature, are observed as the fluid moves between these...
1.9K
02:27Background and Environment Affect Phenotype
7.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.5K
01:35Pedigree Analysis
89.0K
Overview
89.0K