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Updated: Jan 23, 2026

Digital Microfluidics for Automated Proteomic Processing
Published on: November 6, 2009
All-in-one automated microfluidics control system
Craig Watson1, Samuel E Senyo1
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Abstract:
We present a fully-integrated solution for controlling pneumatically-driven microfluidic chips, featuring a pump, one or more pressure regulators and up to 32 solenoid valves, controlled by a microcontroller. The microfluidics control system requires only a power source and a computer or mobile device for its operation. A touchscreen interface communicates with the microcontroller over USB or Bluetooth and allows users to control the system with ease either manually or autonomously, allowing experiments to run with no user intervention. The pressure regulators were purpose-built, enabling integrated pressure sources on-board, rather than relying on external equipment. These regulators can also be used as stand-alone devices in any other application.
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