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Updated: Jan 23, 2026
09:03
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
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Coccidioidomycosis in solid organ transplant recipients
Deepa D Nanayakkara1, Emily Blodget2
1Division of Infectious Diseases, David Geffen School of Medicine at University of California Los Angeles.
Current Opinion in Organ Transplantation
|June 14, 2019
Summary
Coccidioidomycosis screening and treatment are crucial for solid organ transplant (SOT) patients in endemic areas. Early diagnosis and management, including antifungal therapy and prophylaxis, improve outcomes and reduce mortality from this fungal infection.
Area of Science:
- Infectious Diseases
- Transplant Medicine
- Mycology
Background:
- Endemic fungal infections, including coccidioidomycosis, pose significant risks for solid organ transplant (SOT) recipients.
- These infections are a leading cause of morbidity and mortality in immunocompromised individuals post-transplantation.
Purpose of the Study:
- To provide an updated review on the diagnosis and treatment of coccidioidomycosis in SOT patients.
- To highlight current recommendations for screening, management, and prophylaxis.
Main Methods:
- Review of current literature and guidelines for coccidioidomycosis in SOT recipients.
- Discussion of screening strategies, diagnostic methods, and therapeutic approaches.
Main Results:
- Screening for coccidioidomycosis in endemic areas includes serologic testing and chest imaging.
- Pretransplant seropositivity rates in endemic regions range from 1.4% to 5.6%.
- Cerebrospinal fluid evaluation is recommended for immunocompromised patients with elevated titers, even if asymptomatic.
Conclusions:
- All SOT patients require treatment for coccidioidomycosis, irrespective of disease severity.
- Treatment may involve intravenous amphotericin B for severe cases or fluconazole for milder episodes.
- Lifelong fluconazole prophylaxis is recommended for SOT recipients with a history of coccidioidomycosis to prevent recurrence.
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