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Related Experiment Video

Updated: May 11, 2026

Rapid Antimicrobial Susceptibility Testing by Stimulated Raman Scattering Imaging of Deuterium Incorporation in a Single Bacterium

Rapid Antimicrobial Susceptibility Testing by Stimulated Raman Scattering Imaging of Deuterium Incorporation in a Single Bacterium

Published on: February 14, 2022

Rapid and Robust Identification of Sepsis Using SeptiCyte RAPID in a Heterogeneous Patient Population.

Robert Balk¹, Annette M Esper², Greg S Martin²

¹Rush Medical College and Rush University Medical Center, Chicago, IL 60612, USA.

Journal of Clinical Medicine

|October 26, 2024

Summary

This summary is machine-generated.

SeptiCyte RAPID, a sepsis diagnostic test, accurately distinguishes sepsis from systemic inflammation across diverse patient groups. Its performance remained consistent, even in complex cases like septic shock.

Keywords:

SIRS SeptiCyte host immune response phenotype sepsis sepsis likelihood stratification

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Area of Science:

* Sepsis diagnostics
* Host response assays
* Clinical microbiology

Background:

* SeptiCyte RAPID is a rapid transcriptional host response assay.
* It differentiates sepsis from systemic inflammatory response syndrome (SIRS).
* Previous studies established its overall performance in a large patient cohort.

Purpose of the Study:

* To evaluate SeptiCyte RAPID performance in diverse patient subgroups.
* To identify factors influencing diagnostic accuracy for sepsis.
* To assess potential challenges in specific patient populations.

Main Methods:

* Stratification analysis of a 419-patient cohort.
* Conventional statistical tests for demographic and clinical subgroups.
* Principal component and k-means clustering for phenotypic subgroup analysis.

Main Results:

* SeptiCyte RAPID demonstrated consistent performance across most patient groups.
* Enhanced performance was noted in a subgroup exhibiting septic shock characteristics.
* No significant performance variations were observed due to demographics, comorbidities, or pathogen types.

Conclusions:

* SeptiCyte RAPID is a robust diagnostic tool for sepsis.
* Its accuracy is largely unaffected by patient heterogeneity.
* The assay shows promise for rapid sepsis diagnosis in varied clinical settings.