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The effect of peripheral nervous system in growing bone biomechanics. An experimental study
Ioannis Gkiatas1, Ioannis Kostas-Agnantis1, Symeon Agathopoulos2
1Department of Orthoapedic Surgery, School of Medicine, University of Ioannina, Ioannina, Greece.
Objective:
There are several factors which affect bone growth. One of them is the peripheralnervous system whose effect on the biomechanics has not been extensively studied. The purpose of this study is to assess the effect of peripheral nervous system in bone biomechanics in an experimental rat model.
Materials & Methods:
27 male Wistar rats were used. In all animals, the roots of the right brachial plexus were dissected and after that the animals were divided into three groups A, B and C. The animals were sacrificed six, nine, and twelve months respectively after the denervation. Both humerus were resected and biomechanical analysis was performed.
Results:
According to the findings of the present study the denervated bones sustain less loading before fracture and they become also more elastic. Additionally, in greater time after denervation plastic deformity is noticed.
Conclusion:
Apart from structural changes, the peripheral nerves are responsible for biomechanic changes in the bones such the greater elasticity of the bone and the reduced strength.
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