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Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Pressure Imbalances and Circulatory Shock01:24

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Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
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Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
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Shock Waves01:16

Shock Waves

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While deriving the Doppler formula for the observed frequency of a sound wave, it is assumed that the speed of sound in the medium is greater than the source's speed through it. When this condition is breached, a shock wave occurs.
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pre-mRNA Processing02:01

pre-mRNA Processing

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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
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Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
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Pre-clinical study protocol: Blood transfusion in endotoxaemic shock.

Nchafatso G Obonyo1,2, Liam Byrne1,3,4, John-Paul Tung1,5,6,7

  • 1Critical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.

Methodsx
|June 14, 2019
PubMed
Summary

This study protocol outlines a preclinical trial investigating early packed red blood cell (PRBC) transfusion for hemodynamic support in sepsis. It aims to clarify the volume expansion effects of PRBCs versus traditional fluids.

Keywords:
Blood transfusionEndotoxaemic shockGuidelinesHaemoglobin thresholdPacked red blood cells (PRBCs)SepsisStorage duration

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Area of Science:

  • Critical Care Medicine
  • Transfusion Medicine
  • Hemodynamics

Background:

  • Current sepsis guidelines offer varied recommendations for blood transfusion thresholds.
  • Volume expansion with crystalloids/colloids in sepsis is linked to adverse outcomes.
  • Hemodynamic effects of early packed red blood cell (PRBC) transfusion in sepsis remain unclear.

Purpose of the Study:

  • To describe a preclinical randomized controlled trial protocol.
  • To examine the hemodynamic effects of early PRBC transfusion as initial volume expansion in a sepsis model.
  • To explore underlying physiological, hematological, immunological, and tissue-specific mechanisms of PRBC transfusion.

Main Methods:

  • Utilizing a validated ovine model of hyperdynamic endotoxemic shock.
  • Designing a preclinical randomized controlled trial.
  • Comparing early PRBC transfusion (before crystalloids/colloids) with other resuscitation strategies.
  • Investigating effects of short (≤5 days) versus long (≥30 days) PRBC storage durations.

Main Results:

  • This section will report findings from the described preclinical trial once completed.

Conclusions:

  • This study protocol provides a framework for investigating the role of early PRBC transfusion in sepsis resuscitation.
  • Findings may inform future clinical guidelines on transfusion strategies for septic shock.