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Updated: May 19, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
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Published on: February 14, 2017

Cardiac surgery modulates leucocyte subsets and inflammatory mediators.

Alexis J Perros1, Kelly Rooks2, Fenny Chong2

  • 1Strategic Transformation and Readiness, Australian Red Cross Lifeblood, PO Box 41, Everton Park, QLD, 4053, Australia; Faculty of Medicine, University of Queensland, 20 Weightman St, Herston, QLD, 4006, Australia; School of Health, University of the Sunshine Coast, Locked Bag 4, Maroochydore DC, QLD, 4558, Australia; Critical Care Research Group (CCRG), The Prince Charles Hospital, 627 Rode Rd, Chermside, QLD, 4032, Australia.

Immunology Letters
|May 17, 2026
PubMed
Summary

Coronary artery bypass grafting (CABG) alters immune cell counts and cytokine levels, impacting patient recovery. Comprehensive analysis of leucocyte subsets can guide post-operative care and predict outcomes like atrial fibrillation and ICU length of stay.

Keywords:
Cardiac surgeryCytokinesInnate immune cellsLymphocytesTranslational immunology

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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Area of Science:

  • Immunology
  • Cardiovascular Surgery
  • Hematology

Background:

  • Leukocytes and cytokines are crucial for immune responses and host defense.
  • Coronary artery bypass grafting (CABG) triggers a systemic inflammatory response, potentially leading to adverse patient outcomes.
  • Standard full blood counts (FBC) offer limited insight into specific leukocyte subsets.

Purpose of the Study:

  • To investigate the impact of CABG on circulating leukocyte subsets and plasma cytokine levels.
  • To explore the relationship between CABG-induced immunomodulation and patient outcomes, specifically atrial fibrillation (AF) and intensive care unit length of stay (ICU LOS).

Main Methods:

  • Whole blood samples were collected from 75 CABG patients at five time-points: admission, intra-operative, ICU, day 3 (D3), and day 5 (D5).
  • Absolute counts of monocytes, NK cells, B cells, T cell subsets, and dendritic cell (DC) subsets were measured using Trucount tubes.
  • Plasma cytokine levels were quantified using cytometric bead array, and FBC data were used to calculate lymphocyte monocyte and neutrophil lymphocyte ratios.

Main Results:

  • Monocyte counts increased, while T-cell counts decreased post-ICU admission compared to baseline.
  • B-cell counts initially decreased during surgery, then rose from D3 onwards.
  • Classical DC numbers decreased, and plasmacytoid DC numbers increased during CABG, alongside elevated IL-6, MCP-10, and IP-10 plasma levels.
  • Modulation of DC and T-cell subsets correlated with AF and ICU LOS.

Conclusions:

  • CABG significantly alters circulating leukocyte subsets and plasma cytokine profiles.
  • Comprehensive analysis of leukocyte subsets and ratios offers valuable insights into cardiac immunobiology post-CABG.
  • Detailed hematological assessment can serve as a clinical tool for guiding postoperative management and predicting patient outcomes.