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Total hip arthroplasty for a woman with hemophilia A -case report

Akio Kanda1, Kazuo Kaneko2, Osamu Obayashi3

  • 1Department of Orthopaedic Surgery, Juntendo Shizuoka Hospital, Izunagaoka 1129, Izunokuni-country, 410-2295, Shizuoka, Japan.

Annals of Medicine and Surgery (2012)
|June 14, 2019
PubMed

Hemophilia A is a congenital bleeding disorder caused by an X-linked hereditary pattern. Female hemophilia A carriers are usually asymptomatic, although some have far lower levels of clotting factor because more X chromosomes with the normal gene are switched off, a phenomenon referred to as "lyonization." During a medical checkup at our hospital, a 56-year-old Japanese woman with coxalgia was also diagnosed as an obligate hemophilia A carrier based on World Federation of Hemophilia criteria. She underwent total hip arthroplasty using blood product coagulation factor VIII to address her hemophilia. Immediate female relatives (mother, sisters, daughters) of a person with hemophilia should have their clotting factor levels checked, especially prior to any invasive intervention or childbirth, or if any symptoms occur.

Keywords:
Clotting factor VIIIFemale hemophilia A carrierTotal hip arthroplasty

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