Updated developments on molecular imaging and therapeutic strategies directed against necrosis

Area of Science:

• Biomedical Imaging
• Molecular Biology
• Theranostics

Background:

• Cell death is integral to organismal health and disease, including cancer, cardiovascular diseases, sepsis, and pancreatitis.
• Noninvasive cell death visualization aids disease insight, personalized treatment, response evaluation, and prognosis prediction.
• While apoptosis and necrosis are key cell death types, this review focuses on necrosis-targeted theranostics.

Purpose of the Study:

• To review current molecular imaging probes and therapeutic strategies targeting necrosis.
• To identify and discuss biomarkers associated with necrotic cells for imaging and therapy.
• To explore future research directions for necrosis imaging and treatment.

Main Methods:

• Literature review of molecular imaging probes and therapeutic strategies for necrosis.
• Analysis of biomarkers indicative of necrotic cell membrane rupture and content release.
• Discussion of challenges and future prospects in necrosis theranostics.

Main Results:

• Necrosis exhibits distinct characteristics like cell membrane rupture, providing targets for imaging and therapy.
• Development of molecular imaging probes and therapeutic strategies targeting necrotic cell biomarkers is ongoing.
• Several potential necrosis biomarkers warrant further investigation for clinical applications.

Conclusions:

• Targeting necrosis offers a promising avenue for disease theranostics, particularly in cancer.
• Advancements in molecular imaging and therapeutic strategies are crucial for effective necrosis-based treatments.
• Further research into novel necrosis biomarkers is essential for improved diagnostic and therapeutic outcomes.