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Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
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Bile Acids and Portal Hypertension
Juan Pablo Arab1, Francisco Barrera2, Marco Arrese2
1Departamento de Gastroenterología, Escuela de Medicina. Pontificia Universidad Católica de Chile. Santiago, Chile; Division of Gastroenterology and Hepatology, Mayo Clinic. Rochester, MN, USA.
Annals of Hepatology
|June 15, 2019
Summary
Bile acid (BA) receptors like FXR and TGR5 are key to understanding vasorelaxation. Modulating these pathways shows promise for treating portal hypertension (PHT).
Area of Science:
- Biochemistry
- Physiology
- Pharmacology
Background:
- Bile acids (BAs) have recognized vasoactive properties, with mechanisms now being elucidated.
- Bile acid receptors, including FXR and TGR5, are present in endothelial cells and influence circulation.
- Recent advancements have revitalized research into the multifaceted roles of BAs.
Purpose of the Study:
- To review current understanding of BA-dependent pathways in portal hypertension (PHT).
- To explore the therapeutic potential of modulating BA receptors for PHT treatment.
Main Methods:
- Review of recent scientific literature on bile acids, their receptors, and PHT.
- Analysis of preclinical data from genetically engineered mouse models and BA receptor agonists.
Main Results:
- FXR and TGR5 receptors play significant roles in systemic and portal circulation.
- Modulation of FXR, and to a lesser extent TGR5, has shown promising preclinical results in PHT models.
- BA-dependent pathways influence multiple processes critical to PHT.
Conclusions:
- Targeting BA-dependent pathways, particularly FXR, offers a promising therapeutic strategy for portal hypertension.
- Further research into BA receptor modulation could lead to novel treatments for PHT.
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