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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
Published on: December 28, 2010
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Theta-burst transcranial magnetic stimulation induced functional connectivity changes between dorsolateral prefrontal
Yuanqi Shang1, Da Chang1, Jian Zhang1
1Center for Cognition and Brain Disorders, Institutes of Psychological Science, Hangzhou Normal University, Hangzhou, China.
Brain Imaging and Behavior
|June 15, 2019
Summary
Repetitive transcranial magnetic stimulation (rTMS) can alter brain connectivity. This study shows continuous theta burst stimulation (cTBS) applied to the left dorsolateral prefrontal cortex reduces functional connectivity with the default mode network in healthy individuals.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
Background:
- Functional connectivity (FC) is crucial for brain function and implicated in disorders.
- Non-invasive modulation of FC is of significant scientific and clinical interest.
- Transcranial magnetic stimulation (TMS) affects targeted and remote brain areas.
Purpose of the Study:
- To investigate if TMS can alter functional connectivity (FC) between brain regions.
- To examine the effects of continuous theta burst stimulation (cTBS) on FC in healthy brains.
Main Methods:
- Used resting-state functional magnetic resonance imaging (fMRI) to measure FC.
- Applied real and control (SHAM) cTBS to the left dorsolateral prefrontal cortex (lDLPFC).
- Calculated FC changes before and after stimulation.
Main Results:
- Repetitive TMS (rTMS) significantly reduced FC between the lDLPFC and default mode network (DMN) regions compared to SHAM.
- This demonstrates that rTMS can modulate FC in healthy brains.
- The observed reduction in FC may stem from the inhibitory effects of cTBS.
Conclusions:
- TMS, specifically cTBS, can effectively reduce functional connectivity between the targeted lDLPFC and DMN.
- This finding supports the potential of TMS as a tool for modulating brain network activity.
- Understanding TMS effects on FC has implications for treating neuropsychiatric disorders.
Keywords:
Cerebral blood flow (CBF)Default mode networkDorsolateral prefrontal cortexFunctional connectivityTranscranial magnetic stimulation (TMS)More Related Videos
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