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Isolation and characterization of a light chain variable region gene for human rheumatoid factors
P P Chen1, D L Robbins, F R Jirik
1Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037.
The Journal of Experimental Medicine
|December 1, 1987
Abstract:
Previously, we isolated a Vk gene (Humkv325) from a human placenta that encodes RF light chains bearing the PSL2 and PSL3 CRI markers. Here we report the isolation and characterization of a second human Vk gene (Humkv328) that can be used for RF synthesis. This Vk gene probably encodes at least two 6B6.6 CRI+ RF light chains (Les and Pom) from unrelated subjects, and thus may be related to the light chain-associated 6B6.6 CRI.