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Simple and Effective Administration and Visualization of Microparticles in the Circulatory System of Small Fishes Using Kidney Injection
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Acute effects of haemodialysis on circulating microparticles

Philip de Laval1, Fariborz Mobarrez2, Tora Almquist3

  • 1Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Clinical Kidney Journal
|June 15, 2019
PubMed
Abstract

Insights

Hemodialysis (HD) increases microparticles (MPs) from platelets, endothelial cells, and monocytes. Differences in MP release were observed between low-flux and high-flux dialyzers, suggesting implications for cardiovascular health in dialysis patients.

Area of Science:

  • Cardiovascular Biology
  • Nephrology
  • Biomarker Discovery

Background:

  • Microparticles (MPs) are cell membrane vesicles linked to endothelial dysfunction and cardiovascular mortality in end-stage renal disease.
  • Elevated MP levels are a known risk factor for cardiovascular events in patients undergoing hemodialysis.

Purpose of the Study:

  • To quantify changes in microparticle concentrations during contemporary hemodialysis (HD).
  • To investigate the impact of dialyzer flux (high-flux vs. low-flux) on MP release.

Main Methods:

  • Blood samples collected from 20 HD patients before and 1 hour into HD sessions.
  • Microparticles analyzed via flow cytometry with specific surface marker phenotyping.

Main Results:

  • Significant increases in platelet-, endothelial-, and monocyte-derived MPs during HD.
  • Upregulation of MPs expressing tissue factor (TF), Klotho, and RAGE observed.
  • Higher increases in endothelial, monocyte, RAGE+, and TF+ platelet-derived MPs with low-flux vs. high-flux dialyzers.

Conclusions:

  • Hemodialysis triggers the release of diverse MPs, with distinct patterns related to dialyzer type.
  • These MPs may influence coagulation, inflammation, oxidative stress, and endothelial dysfunction.
  • Further research is needed to establish the clinical significance of these findings.
Keywords:
KlothoRAGEchronic kidney diseasehaemodialysismicroparticles

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