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Updated: Jan 23, 2026

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
Published on: March 24, 2018
Unique supramolecular complex of diclofenac: structural robustness, crystal-to-crystal solvent exchange, and
Qixuan Zheng1, Samantha L Rood1, Daniel K Unruh1
1Department of Chemistry and Biochemistry, Texas Tech University, 1204 Boston Avenue, Lubbock, Texas 79409, USA. kristin.hutchins@ttu.edu.
Abstract:
We describe an unexpected, cyclic supramolecular complex that results from self-assembly of the nonsteroidal anti-inflammatory drug, diclofenac and 4,4'-azopyridine. The cycles self-assemble into 1D columns occupied by solvent, which can be removed at elevated temperatures (>100 °C) while retaining crystallinity. The complex exhibits solvent exchange ability that occurs through crystal-to-crystal transformations. Finally, the complex can be synthesized using mechanochemistry. Materials exhibiting the structural framework and robustness described here could be applied to removal of hazardous materials or undesirable solvents.
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