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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Methods of Nuclear Reprogramming01:24

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Related Experiment Video

Updated: May 5, 2026

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
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Could iPSCs Enable "Off-the-Shelf" Cell Therapy?

Diana Crow1

  • 1Cambridge, MA, USA.

Cell
|June 15, 2019
PubMed
Summary

Off-the-shelf cell therapies using induced pluripotent stem cells (iPSCs) are advancing into clinical trials. While these therapies offer potential for widespread use, some experts express reservations about their safety and efficacy.

Area of Science:

  • Stem Cell Therapy
  • Regenerative Medicine
  • Clinical Trials

Background:

  • Induced pluripotent stem cells (iPSCs) possess self-renewal capabilities, enabling large-scale cell therapy manufacturing.
  • The development of "off-the-shelf" allogeneic cell therapies aims to reduce costs and improve accessibility compared to autologous treatments.
  • Current advancements focus on utilizing iPSCs to create cell products that do not require patient-specific customization.

Purpose of the Study:

  • To report the initiation of clinical trials for an "off-the-shelf" cell therapy derived from iPSCs in the United States.
  • To highlight the growing trend of companies pursuing iPSC-based cell therapies for broader patient application.
  • To present expert opinions and potential concerns regarding the widespread adoption of these novel therapies.

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Main Methods:

  • Clinical trial initiation in the United States.
  • Leveraging the self-renewal properties of iPSCs for cell therapy production.
  • Manufacturing of non-customized, allogeneic cell therapies.

Main Results:

  • An "off-the-shelf" iPSC-derived cell therapy has commenced clinical trials.
  • Multiple companies are actively developing similar iPSC-based therapeutic approaches.
  • Expert opinions indicate a degree of uncertainty surrounding the viability of these therapies.

Conclusions:

  • The field of iPSC-derived cell therapy is progressing towards clinical application.
  • The "off-the-shelf" model presents a promising avenue for scalable cell-based treatments.
  • Further evaluation and expert consensus are needed to address potential challenges in iPSC therapy implementation.