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[Delayed allergic reaction to furosemide with a positive lymphocyte transformation test]

Olga Patricia Monge-Ortega¹, Javier Domínguez-Ortega, Miguel González-Muñoz

¹Hospital San Juan de Dios, Departamento de Alergia, San José, Costa Rica. patmonor@hotmail.com.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

|June 15, 2019

Abstract

Background:

Furosemide is the most commonly prescribed loop diuretic worldwide. Although, its extended use, furosemide rarely induces allergic reactions. Until 2013, only 49 cases of furosemide allergy had been described.

Clinical Case:

We have reported on a patient who developed a delayed, erythematous and pruritic skin eruption after the ingestion of furosemide. The implication of furosemide in the reaction was established by a positive lymphocyte transformation test (LTT).

Conclusion:

This is the first reported case of hypersensitivity to furosemide in which this drug was confirmed as the trigger by a positive LTT. LTT could become a decent diagnostic alternative for patients who experience delayed reactions to furosemide.

Keywords:

Allergy Delayed reaction Furosemide Lymphocyte transformation test

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