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SNIPERs-Hijacking IAP activity to induce protein degradation

Mikihiko Naito1, Nobumichi Ohoka1, Norihito Shibata1

  • 1Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki 210-9501, Japan.

Drug Discovery Today. Technologies
|June 16, 2019
PubMed
Summary

Specific and non-genetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs) induce targeted protein degradation. SNIPERs degrade IAPs and target proteins, offering a novel strategy for cancer therapy.

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