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Targeting pro-senescence mitogen activated protein kinase (Mapk) enzymes with bioactive natural compounds

Mercedes Cano1, Angelica Guerrero-Castilla2, Seyed Mohammad Nabavi3

  • 1Department of Physiology, Faculty of Pharmacy, University of Seville, Seville, Spain.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|June 16, 2019
PubMed

Insights

Cellular senescence drives aging and inflammation. Natural compounds targeting Mitogen Activated Protein Kinases (MAPK) pathways may inhibit senescence, potentially extending lifespan and preventing age-related diseases.

Area of Science:

  • Gerontology and Molecular Biology
  • Focuses on the molecular mechanisms underlying aging and the development of interventions.

Background:

  • Aging is a universal process involving decreased physiological functions.
  • Cellular senescence and immunesenescence are key aging hallmarks, promoting inflammation and hindering tissue repair.
  • Mitogen Activated Protein Kinases (MAPK) pathway dysregulation is linked to aging and senescence.

Purpose of the Study:

  • To review the role of MAPK pathways in aging.
  • To identify natural compounds with anti-senescence properties.
  • To explore the potential of these compounds in longevity and age-related disease prevention.

Main Methods:

  • Summarized components of the MAPK pathway (ERK1/2, JNK, p38).
  • Reviewed natural compounds including flavonoids, phenolics, and diterpenoids with anti-senescence activity.
  • Examined the effects of these compounds on MAPK inhibition and senescent cell reduction.

Main Results:

  • Dysregulation of MAPK enzymes is associated with aging and irreversible senescence.
  • Certain natural compounds demonstrate anti-senescence activity and can inhibit MAPK pathways.
  • These compounds show potential for promoting longevity.

Conclusions:

  • Natural bioactive compounds that modulate MAPK pathways and reduce senescent cells offer a promising avenue for intervention.
  • Further research in diverse aging models is needed to validate these findings.
  • These compounds could potentially improve longevity and treat age-related diseases.
Keywords:
AgingAnti-senescence compoundsBioactive compoundsMAPK pathwaySenescence

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