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Is human leukocyte antigen-matched sibling donor transplant always better than haploidentical allograft?

Ying-Jun Chang1, Xiao-Jun Huang2

  • 1Peking University People's Hospital and Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Xicheng District, Beijing, China.

Seminars in Hematology
|June 17, 2019
PubMed

Currently, haploidentical donor has been an alternative source of stem cell allografts for patients who have no human leukocyte antigen-matched sibling donor or unrelated donors. A number of studies indicated that treating hematological malignancy patients with haploidentical stem cell transplantation (haplo-SCT) could achieve comparable outcomes to those who underwent matched sibling donor transplantation (MSDT). In recent years, more and more evidence support the notion that haploidentical allografts may have a stronger graft-vs-leukemia (GVL) effect than MSDT. In this review, we summarized the transplant outcomes of haplo-SCT and MSDT, mainly focusing on the subgroup of patients who will benefit from the stronger GVL effects of haplo-SCT compared with MSDT. We also offered strategies of how to translate the strong antileukemia activity of haploidentical allograft into superior survival. Future directions of GVL effects in haplo-SCT settings were also discussed.

Keywords:
Graft-vs-leukemia effectsHaploidentical stem cell transplantationHuman leukocyte antigen-matched sibling donor transplantation

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