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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
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Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction: Understanding Mechanisms by Using
Masaru Obokata1, Yogesh N V Reddy1, Barry A Borlaug1
1Department of Cardiovascular Medicine, Mayo Clinic and Foundation, Rochester, Minnesota.
JACC. Cardiovascular Imaging
|June 17, 2019
Summary
Understanding heart failure with preserved ejection fraction (HFpEF) is advancing, but effective treatments are lacking. Echocardiography can help identify HFpEF patient phenotypes for targeted therapy.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Heart failure with preserved ejection fraction (HFpEF) pathophysiology is better understood, yet treatment options remain limited.
- Clinical trial failures in HFpEF may stem from its mechanistic heterogeneity.
- Phenotyping HFpEF patients is crucial for developing targeted therapies.
Purpose of the Study:
- To review the current understanding of HFpEF pathophysiology and phenotyping.
- To highlight the role of echocardiography in diagnosing and characterizing HFpEF.
- To discuss how echocardiography can guide personalized treatment strategies.
Main Methods:
- Review of recent research on HFpEF pathophysiology and treatment.
- Emphasis on echocardiographic techniques for HFpEF evaluation.
- Analysis of diagnostic value of E/e' ratio and right ventricular systolic pressure.
Main Results:
- Echocardiography offers insights into HFpEF pathophysiology and patient phenotypes.
- The E/e' ratio combined with right ventricular systolic pressure aids HFpEF diagnosis.
- Echocardiography differentiates HFpEF mimics like valvular disease and cardiac amyloidosis.
Conclusions:
- Echocardiography is vital for phenotyping HFpEF patients.
- Identifying underlying causes and phenotypes improves diagnostic accuracy.
- Personalized treatment approaches for HFpEF may be facilitated by echocardiography.
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