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Methotrexate in the Treatment of Idiopathic Granulomatous Mastitis
Anna Postolova1,2, Megan L Troxell3,4, Irene L Wapnir3,4
1From the Division of Immunology and Rheumatology, Department of Pathology, Department of Surgery, Stanford University School of Medicine, Palo Alto, California, USA. postolov@stanford.edu.
Objective:
Idiopathic granulomatous mastitis (IGM) is a disfiguring inflammatory breast disease without effective treatment. We report the largest IGM cohort treated with methotrexate (MTX) monotherapy.
Methods:
Chart review was performed on patients evaluated by the Stanford Immunology and Rheumatology Clinic, with histopathologically established IGM treated with MTX, and at least 1 followup appointment.
Results:
Nineteen female patients with a mean age of 33.5 years were identified. Most failed treatment with antibiotics, prednisone, and surgical intervention. By 15 months of treatment with MTX, 94% had disease improvement and 75% achieved disease remission.
Conclusion:
MTX monotherapy is an effective treatment for IGM.
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