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Related Experiment Video

Updated: Jan 23, 2026

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
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Quantification of interventricular dyssynchrony during continuous-flow left ventricular assist device support.

Junichi Shimamura1,2, Takashi Nishimura3, Toshihide Mizuno4

  • 1Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 5-7-1, Fujishirodai, Suita, Osaka, 565-8565, Japan. junichi.shimamura@gmail.com.

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
|June 17, 2019
PubMed
Summary

Continuous-flow left ventricular assist device (CF-LVAD) support causes interventricular dyssynchrony, increasing with LV unloading. This study quantifies dyssynchrony during CF-LVAD support, revealing its link to reduced left ventricular stroke volume.

Keywords:
Conductance methodContinuous-flow left ventricular assist deviceInterventricular dyssynchronyPressure–volume loop

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Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering

Background:

  • Continuous-flow left ventricular assist devices (CF-LVADs) are crucial for heart failure management.
  • CF-LVAD support can lead to dyssynchrony between the left ventricle (LV) and right ventricle (RV) due to altered LV systole.

Purpose of the Study:

  • To quantify interventricular dyssynchrony under various CF-LVAD support levels.
  • To assess the relationship between interventricular dyssynchrony and left ventricular unloading.

Main Methods:

  • Seven goats with normal hearts were studied under general anesthesia.
  • A centrifugal LVAD was implanted, and conductance catheters measured simultaneous LV and RV volumes.
  • Interventricular dyssynchrony was defined as opposing volume changes between LV and RV (dLVV/dt × dRVV/dt < 0).

Main Results:

  • Mean dyssynchrony duration (DYS) increased with CF-LVAD support: normal hearts (5.6%), LVAD clamp (8.7%), 50% bypass (8.6%), 75% bypass (15.1%), and 100% bypass (25.6%).
  • A significant positive correlation was observed between DYS and the degree of LV unloading.
  • LV unloading directly impacts interventricular synchrony.

Conclusions:

  • Interventricular dyssynchrony is a quantifiable consequence of CF-LVAD support.
  • The degree of dyssynchrony escalates with increasing LV unloading.
  • Findings provide insights into interventricular interactions during CF-LVAD support, suggesting further research into RV function and heart failure models.