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A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
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Performance evaluation of quantitative SPECT/CT using NEMA NU 2 PET methodology
HyunJu Ryu1,2, Steven R Meikle1,3, Kathy P Willowson4
1Faculty of Health Sciences, University of Sydney, Lidcombe, NSW, Australia.
Physics in Medicine and Biology
|June 18, 2019
Summary
Standard methodology for quantitative single-photon emission computed tomography (SPECT) system evaluation is lacking. This study adapted NEMA NU2 standards for SPECT/CT, demonstrating its utility for routine quality assurance in clinical settings.
Area of Science:
- Nuclear Medicine
- Medical Imaging Physics
Background:
- Quantitative performance evaluation is crucial for SPECT/CT systems.
- Established methodologies like NEMA NU2 are standard for PET/CT but not SPECT/CT.
- This study addresses the need for standardized SPECT/CT performance assessment.
Purpose of the Study:
- To evaluate the quantitative performance of the Symbia Intevo SPECT/CT system.
- To benchmark SPECT/CT performance against a PET/CT system using common isotopes (99mTc, 177Lu for SPECT; 18F, 68Ga for PET).
- To demonstrate the adaptability of NEMA NU2 PET standards for SPECT/CT quantitative evaluation.
Main Methods:
- Evaluation of SPECT/CT quantitative performance using NEMA NU2 methodology.
- Benchmarking against PET/CT performance for key metrics.
- Assessment of dead-time, resolution recovery, sensitivity, scatter fraction, contrast recovery, and background variability.
- Utilized the NEMA IQ phantom with varying sphere sizes.
Main Results:
- SPECT/CT spatial resolution was 13.1 mm (99mTc) and 22.4 mm (177Lu), compared to PET's 4.3 mm (18F) and 5.8 mm (68Ga).
- SPECT sensitivity was significantly lower than PET (e.g., 119 cps/MBq for 99mTc vs. 9632 cps/MBq for 18F).
- Full contrast recovery in the NEMA IQ phantom was achieved for PET (17mm sphere for 18F) but not for SPECT across any sphere size.
Conclusions:
- The NEMA NU2 methodology is adaptable for SPECT/CT quantitative performance evaluation.
- This adapted methodology can serve as a routine quality assurance procedure in clinical practice.
- While quantitative performance metrics differ between SPECT and PET, standardized evaluation is feasible.
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