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Charting and Evaluation of Real-Time Continuous Monitoring Water Bioburden
1BR Consulting, Ness Ziona, Israel 7403774.
PDA Journal of Pharmaceutical Science and Technology
|June 19, 2019
Summary
Statistical analysis of municipal water bioburden data effectively reduces autocorrelation in high-frequency readings. Batch means control charts transform data for clearer process monitoring and fewer false alarms.
Area of Science:
- Environmental Science
- Statistical Process Control
- Microbiology
Background:
- Continuous monitoring of municipal water bioburden generates high-frequency data.
- Laser-induced fluorescence (LIF) analyzers produce positively autocorrelated data streams.
- Autocorrelation in data complicates interpretation and increases false alarms on Shewhart control charts.
Purpose of the Study:
- To analyze municipal water bioburden data to minimize autocorrelation.
- To improve the charting and evaluation of monitoring process behavior.
- To establish when to take action to maintain the process under statistical control.
Main Methods:
- Application of statistical analysis to high-frequency bioburden data.
- Utilized model-based and model-free methods to address data autocorrelation.
- Compared skip sampling, time series models, and batch means control charts.
Main Results:
- Skip sampling and time series models successfully removed autocorrelation.
- Batch means control charts, a model-free method, were favored for practical application.
- Averaging successive data points into batches reduced data frequency and improved interpretability.
Conclusions:
- Batch means control charts, with practically determined limits, convert high-frequency data to low-frequency data.
- This method results in standard control charts with fewer false alarms, revealing underlying process trends more clearly.
- The approach is applicable to environmental monitoring of inert particles and microbes in controlled environments.
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