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Chirality

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...

Chirality in Nature

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.

Group Polarization

Group Polarization

Group polarization is the strengthening of an original group attitude following the discussion of views within a group (Teger & Pruitt, 1967). That is, if a group initially favors a viewpoint, after discussion the group consensus is likely a stronger endorsement of the viewpoint. Conversely, if the group was initially opposed to a viewpoint, group discussion would likely lead to stronger opposition.

Molecular Shape and Polarity

Molecular Shape and Polarity

Dipole Moment of a Molecule

Molecules with Multiple Chiral Centers

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...

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Related Experiment Video

Updated: Jan 23, 2026

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

Circularly Polarized Light Triggers Biosensing Based on Chiral Assemblies.

Changlong Hao¹, Liguang Xu¹, Maozhong Sun¹

¹International Joint Research Laboratory for Biointerface and Biodetection, State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|June 19, 2019

Summary

Researchers created a novel chiral assembly using DNAzymes and nanoparticles. This probe detects intracellular metal ions using light, enabling simultaneous multi-analyte sensing in living cells.

Keywords:

DNAzymes chiral assemblies circularly polarized light detection metal ions

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A Photonic System for Generating Unconditional Polarization-Entangled Photons Based on Multiple Quantum Interference

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Published on: September 5, 2019

Area of Science:

Nanotechnology
Biochemistry
Materials Science

Background:

Chiral assemblies are crucial for applications like sensing and catalysis.
Developing sophisticated chiral structures is an ongoing research area.

Purpose of the Study:

To construct a novel chiral core-satellite assembly using DNAzymes.
To develop a photothermally activated probe for simultaneous multi-analyte detection in living cells.

Main Methods:

Utilized specific DNAzymes to create a DNAzyme-driven spiny nanorod dimer core.
Integrated upconversion nanoparticles (UCNPs) as satellites to form the chiral assembly.
Employed 980 nm left circularly polarized (LCP) light for activation and detection.

Main Results:

Successfully constructed a geometrically chiral core-satellite assembly.
Demonstrated the probe's ability to quantify and visualize intracellular metal ions.
Showcased simultaneous detection of multiple analytes under LCP light illumination.

Conclusions:

The developed chiral assembly serves as an effective photothermal probe.
This technology enables sensitive and simultaneous detection of intracellular metal ions.
The probe holds potential for advanced biological sensing and imaging applications.