Related Experiment Video
Updated: Jan 23, 2026

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
Published on: February 1, 2017
[Hepatitis D virus: viral cycle and new therapeutic approaches]
Vincent Turon-Lagot1, Antonio Saviano1, Catherine Schuster1
1Université de Strasbourg, Inserm, Institut de recherche sur les maladies virales et hépatiques UMR_S1110, F-67000 Strasbourg, France.
Abstract:
An estimated 70 million people are chronically infected with hepatitis D (delta) virus (HDV) worldwide. HDV is a small satellite virus of hepatitis B virus (HBV) requiring HBV for the completion of its cycle. Hepatitis D is the most severe form of chronic viral hepatitis. It is responsible for an acceleration and an aggravation of chronic liver disease compared to HBV monoinfected patients. Current treatments based on pegylated interferon rarely allow viral clearance in chronically infected patients. For long time, the absence of easy-to-use models has limited the knowledge on virus-host interactions. Notably, hepatocyte host factors involved in the viral life cycle remain largely unknown. These host factors are potential therapeutic targets for novel treatment strategies, including molecules currently evaluated in clinical trials. This review summarizes our knowledge on HDV molecular virology and innovative therapeutic strategies targeting hepatocyte host factors.
Related Concept Videos
Viral Replication: Lysogenic Cycle
Viral Replication: Lytic Cycle
Hepatic Drug Excretion: Enterohepatic Cycling
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
Lytic Cycle of Bacteriophages
What are Viruses?
Viral Recombination

