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Updated: Jan 23, 2026

Lung Tumor Cell Recruitment Assay
Published on: February 26, 2019
Pneumothorax in neuromuscular disease associated with lung volume recruitment and mechanical
Luke Andrew McDonald1, David John Berlowitz1,2,3,4, Mark Erskine Howard2,3
1Department of Physiotherapy Austin Health Heidelberg Victoria Australia.
Abstract:
A 25-year-old male with Duchenne muscular dystrophy and a 73-year-old male with motor neurone disease both presented with chest pain and increasing dyspnoea following routine mechanical insufflation-exsufflation or lung volume recruitment, on a background of long-term non-invasive ventilation. In each case, chest radiograph revealed a pneumothorax. In both cases the pneumothorax fully resolved following insertion of an intercostal catheter. There was no immediate recurrence and the patients were discharged home and ceased ongoing prophylactic respiratory therapy, although one person had recurrent pneumothoraces subsequently. This rare but serious complication highlights the need for careful risk/benefit analysis by clinicians prescribing these therapies.
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