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Updated: Jan 23, 2026

Imaging and Analysis of Neurofilament Transport in Excised Mouse Tibial Nerve
Published on: August 31, 2020
CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis
Marc Pawlitzki1,2, Michaela Butryn1, Florian Kirchner3
1Department of Neurology Otto-von-Guericke University Leipziger Straße 44 39120 Magdeburg Germany.
Abstract:
The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the disease. A marked increase in NFL levels preceding the onset of neuro-axonal damage and arterial-vessel abnormalities was observed with magnetic resonance imaging as well as with MR- and conventional angiography. Thus, marked elevation of NFL in PACNS seems to occur ahead of definitive radiological abnormalities and might serve as a diagnostic biomarker.
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