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Surgical Resection and Pazopanib Treatment for Recurrent Cardiac Angiosarcoma

Yuki Nakamura1, Koichi Toda1, Shigeru Miyagawa1

  • 1Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.

Clinical Pathology (Thousand Oaks, Ventura County, Calif.)
|June 19, 2019
PubMed

Insights

Recurrent cardiac angiosarcoma poses challenges, but aggressive surgery combined with pazopanib (a tyrosine kinase inhibitor) shows promise. This approach led to a 2-year remission in a patient, improving survival for this rare cancer.

Area of Science:

  • Cardiovascular Surgery
  • Medical Oncology
  • Sarcoma Research

Background:

  • Cardiac sarcoma is difficult to treat due to high recurrence rates and poor prognosis.
  • Effective management strategies for recurrent cardiac sarcoma are lacking.
  • Pazopanib, a multi-targeted tyrosine kinase inhibitor, is approved for soft-tissue sarcoma.

Purpose of the Study:

  • To report a case of recurrent cardiac angiosarcoma treated with repeated surgery and pazopanib.
  • To evaluate the efficacy of this combined treatment approach in improving patient survival.

Main Methods:

  • A patient with recurrent cardiac angiosarcoma underwent repeated surgical resection.
  • The patient received oral pazopanib post-surgery.
  • Disease status and survival were monitored.

Main Results:

  • The patient achieved a 2-year disease remission.
  • Complete remission of recurrent cardiac angiosarcoma was observed.
  • The combined treatment strategy appeared effective in prolonging survival.

Conclusions:

  • Aggressive surgical resection combined with pazopanib may be a viable treatment option for recurrent cardiac angiosarcoma.
  • This approach could potentially improve survival outcomes for patients with this rare and aggressive malignancy.
  • Further research is warranted to validate these findings in a larger cohort.
Keywords:
angiogenesiscardiac angiosarcomapazopanib

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