Related Experiment Video

Updated: Jan 23, 2026

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education
09:00

Author Spotlight: Validation of SICOLE-R for Assessing Cognitive and Reading Skills in Spanish-Speaking Children and Its Role in Personalized Education

Published on: August 16, 2024

1.2K

Advanced Lipid Thinking Prior to Incorporating Advanced Lipid Testing

Kent Brummel1, Nilay Shah2, Neil J Stone2

  • 1University of Chicago, Chicago, Il.

The American Journal of Medicine
|June 19, 2019
PubMed

Insights

Advanced lipid testing refines atherosclerotic cardiovascular disease risk assessment. Utilizing factors like Apolipoprotein B and lipoprotein (a) helps personalize treatment decisions for better cardiovascular event prevention.

Area of Science:

  • Cardiology
  • Clinical Lipidology
  • Preventive Medicine

Background:

  • Lipid profiles are crucial for estimating atherosclerotic cardiovascular disease (ASCVD) risk and guiding treatment.
  • The 2018 cholesterol guidelines recommend advanced lipid testing for specific patient groups.
  • Risk stratification is essential for effective ASCVD prevention strategies.

Purpose of the Study:

  • To outline the role of advanced lipid testing in ASCVD risk assessment.
  • To detail how new guidelines inform the use of advanced lipid testing.
  • To explain the integration of advanced lipid testing into clinical decision-making for ASCVD prevention.

Main Methods:

  • Utilizing 2018 cholesterol guidelines for patient selection.
  • Calculating 10-year ASCVD risk scores for individuals aged 40-75.
  • Incorporating risk-enhancing factors and advanced lipid tests (Apolipoprotein B, lipoprotein (a)) for personalized risk assessment.

Main Results:

  • Advanced lipid testing, including Apolipoprotein B and lipoprotein (a), can refine ASCVD risk estimations.
  • These tests aid in identifying genetic disorders and reclassifying risk in specific patient populations.
  • Risk-enhancing factors personalize decisions for initiating statin therapy in intermediate-risk patients.

Conclusions:

  • Advanced lipid testing optimizes ASCVD prevention by enhancing risk assessment.
  • The decision-making cascade involves risk score calculation, personalization with enhancing factors, and risk reclassification.
  • Integrating advanced lipid testing into clinical practice improves personalized cardiovascular risk management.

Keywords:
Advanced lipid testingApolipoprotein BCoronary artery calcium scoreGuidelinesLipoprotein (a)

More Related Videos

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs09:45

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors GPCRs

Published on: February 5, 2022

4.0K
Determination of Total Lipid and Lipid Classes in Marine Samples14:59

Determination of Total Lipid and Lipid Classes in Marine Samples

Published on: December 11, 2021

5.3K

Related Concept Videos

What are Lipids?01:38

What are Lipids?

Overview
219.4K
What are Lipids?01:31

What are Lipids?

Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and...
10.8K
Lipid Digestion01:06

Lipid Digestion

Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
99.0K
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
98.5K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.1K
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.3K