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[Trauma-Induced Coagulopathy: Pathophysiology and Management]

Christine Schlömmer, Jens Meier

    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
    |June 19, 2019
    PubMed

    Persistent, uncontrolled bleeding after trauma is one of the leading causes of fatalities in patients with severe injuries. 40% of trauma deaths are associated with massive haemorrhage. Hypoperfusion due to major loss of blood volume leads to tissue damage. In combination with acidosis and hypothermia, a generalized immune response with activation of coagulation is triggered. This leads to trauma-induced coagulopathy. A suitable, early treatment might lead to a significant reduction in morbidity and mortality.

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