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Updated: Jan 23, 2026

Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Non-Ionic Deep Eutectic Liquids: Acetamide-Urea Derived Room Temperature Solvents
Subramanian Suriyanarayanan1, Gustaf D Olsson2, Subban Kathiravan3
1Bioorganic & Biophysical Chemistry Laboratory, Linnaeus Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-391 82 Kalmar, Sweden. esusu@lnu.se.
Abstract:
A family of non-ionic deep eutectic liquids has been developed based upon mixtures of solid N-alkyl derivatives of urea and acetamide that in some cases have melting points below room temperature. The eutectic behaviour and physical characteristics of a series of eleven eutectic mixtures are presented, along with a molecular dynamics study-supported hypothesis for the origin of the non-ideal mixing of these substances. Their use as solvents in applications ranging from natural product extraction to organic and polymer synthesis are demonstrated.
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