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Reduction is a simple strategy to convert a carbonyl group to a hydroxyl group. The three major pathways to reduce carbonyls to alcohols are catalytic hydrogenation, hydride reduction, and borane reduction.
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Updated: Jan 9, 2026

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Published on: April 10, 2018

Recent Advancements in Nickel-Catalyzed Electrochemical Reductive Cross-Coupling.

Subban Kathiravan¹, Ian A Nicholls¹

¹Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, Kalmar SE-39182, Sweden.

ACS Organic & Inorganic Au

|December 8, 2025

Summary

Nickel-catalyzed electrochemical cross-coupling offers a sustainable and precise approach to synthetic chemistry. Recent advancements focus on innovative catalysts and conditions for efficient, selective bond formation.

Keywords:

C−C, C−N, C−S, and C−P bond formation C−H activation electrochemical synthesis nickel catalysis organic electrochemistry reductive cross-coupling sustainable chemistry transition-metal catalysis

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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

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Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols

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Published on: April 4, 2014

Area of Science:

Synthetic Chemistry
Electrochemistry
Catalysis

Background:

Nickel catalysis is versatile.
Electrochemical methods offer sustainability and precision.
Combining these offers significant advantages in synthesis.

Purpose of the Study:

To review recent progress in nickel-catalyzed electrochemical cross-coupling since 2015.
To highlight innovative catalysts, reaction conditions, and mechanistic insights.
To emphasize advancements in efficiency, selectivity, and sustainability.

Main Methods:

Literature review of developments from 2015 onwards.
Focus on novel nickel catalysts and reaction conditions.
Analysis of mechanistic insights into electrochemical synergy.

Main Results:

Development of innovative nickel catalysts.
Expansion of substrate scope for cross-coupling reactions.
Elucidation of mechanistic pathways benefiting from electrochemical methods.

Conclusions:

Nickel-catalyzed electrochemical cross-coupling is a rapidly advancing field.
This methodology facilitates complex bond formation under mild, sustainable conditions.
It holds significant potential for green and efficient synthetic chemistry.