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Updated: Jan 9, 2026

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Recent Advancements in Nickel-Catalyzed Electrochemical Reductive Cross-Coupling
Subban Kathiravan1, Ian A Nicholls1
1Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, Kalmar SE-39182, Sweden.
Abstract:
Nickel-catalyzed electrochemical cross-coupling has emerged as an important advancement in synthetic chemistry, combining the versatile catalytic properties of nickel with the sustainability and precision of electrochemical methods. This review captures the recent progress in this dynamic field, focusing on developments published from 2015 onward, and emphasizes the development of innovative catalytic systems and reaction conditions that enhance efficiency, selectivity, and environmental sustainability. Key advancements include novel nickel catalysts, expanded substrate scopes, and mechanistic insights that elucidate the synergistic benefits of electrochemical approaches. By exploring these recent developments, we highlight the transformative potential of nickel-catalyzed electrochemical cross-coupling in facilitating complex bond formation under mild conditions. This comprehensive overview provides a foundation for understanding the current state and future directions of this promising area, emphasizing its significance in advancing green and efficient synthetic methodologies.
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