Long non-coding RNA NEAT1 can predict various malignant tumour lympha node metastasis: a meta-analysis
Lei Zhang1, Zhe Zhang2, Zhenglun Yu2
1a Department of Breast Surgery, The First Hospital Affiliated China Medical University , Shenyang , China.
Artificial Cells, Nanomedicine, and Biotechnology
|June 20, 2019
Summary
High expression of NEAT1, a long non-coding RNA, is linked to lymph node metastasis in various cancers. This finding suggests NEAT1 could be a valuable molecular marker for predicting cancer spread and guiding treatment.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNA (lncRNA) NEAT1 is implicated in malignant tumor progression.
- Tumor development and metastasis frequently involve lymph node involvement.
Purpose of the Study:
- To investigate the role of NEAT1 in lymph node metastasis (LNM) across different cancers.
- To evaluate NEAT1 as a potential biomarker for LNM.
Main Methods:
- Systematic literature search of PubMed, Web of Science, and CNKI databases up to January 10, 2019.
- Meta-analysis of eight studies including 821 patients.
Main Results:
- High NEAT1 expression was significantly associated with lymph node metastasis in malignant tumors.
- High NEAT1 levels predict lymph node metastasis (OR = 3.36, 95% CI = 1.66-6.77, p = .000).
Conclusions:
- NEAT1 is a potential molecular marker for predicting lymph node metastasis.
- Elevated NEAT1 expression may serve as a prognostic indicator in cancer treatment strategies.
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