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Multimodal Optical Diagnostics of Glycated Biological Tissues
O A Smolyanskaya1, E N Lazareva2,3, S S Nalegaev4
1ITMO University, St. Petersburg, 197101, Russia. smolyanskaya@corp.ifmo.ru.
Biochemistry. Biokhimiia
|June 20, 2019
Summary
Spectroscopic methods reveal changes in glycated proteins and hemoglobin, offering new avenues for diabetes diagnostics. These techniques, including digital holographic microscopy, show promise for monitoring disease progression and developing advanced diagnostic tools.
Area of Science:
- Biophysics
- Medical Diagnostics
- Spectroscopy
Background:
- Diabetes mellitus is a complex metabolic disorder marked by chronic hyperglycemia and disruptions in metabolism.
- Long-term diabetes complications include microvascular, macrovascular, and neuropathic changes.
- Protein glycation is a key pathological process in diabetes.
Purpose of the Study:
- To review spectroscopic studies on protein glycation in diabetes.
- To explore the application of optical methods for diabetes diagnostics.
- To analyze novel approaches for monitoring diabetes-related tissue and blood flow changes.
Main Methods:
- Spectroscopic analysis across visible to terahertz radiation.
- Refractometric measurements of hemoglobin using digital holographic microscopy and diffraction tomography.
- Investigation of optical clearing agents for tissue and blood flow monitoring.
Main Results:
- Spectroscopic studies reveal distinct changes in glycated tissues and proteins.
- Digital holographic microscopy and diffraction tomography enable detailed analysis of hemoglobin.
- Multimodal approaches combining phase diagnostics show promise for diabetes detection.
Conclusions:
- Spectroscopic and advanced optical methods offer potential for precise diabetes diagnostics.
- Monitoring glycated proteins and hemoglobin is crucial for understanding disease progression.
- Further development of multimodal diagnostic strategies is recommended for diabetes management.
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